As a result of a radioactive spider bite, high schooler Peter Parker developed powers and abilities similar to that of a spider. After Peter’s selfishness indirectly resulted in the death of his beloved Uncle Ben, Peter decided to live up to the motto that “With great power there must also come great responsibility,” and thus became the superhero known as Spider-Man.

The mantle of Spider-Man has been taken by a number of people, most notably Peter’s clone Ben Reilly, the villainous Otto Octavius and his duplicate, and Miles Morales.